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宗天保任职护卫员的科学园大火，他舍身救了女研究员高玉。但研究所潘教授在大火中不幸辞世，潘教授的手写笔记在大火中消失。大火引发了灰尘风暴，令整个香港被雾霾卷盖。
财阀王耀才投资的“天空一号”，让富人得以远离污染，而已故潘教授的助理唐永章变成他的合作伙伴，唐的发妻高玉继续在天空一号上钻研“超能干细胞”的“再生学”工作，完成潘教授的遗愿。从台湾来的家家带着癌症末期的妹妹小珍来香港求医，怎料两兄妹因此卷入一场“超能力干细胞”的劫案中，而偷走这新科研血清的主脑，竟是已故潘教授的独生子子文，在争夺血清的过程中，子文逐渐发现了令父亲潘教授死亡的真正凶手……。Vishal (Ajay Devgan), a stock analyst, and his wife Swati (Urmila Matondkar). The two are in search for a flat in Mumbai. Vishal finds the perfect place on the 12th floor of a high-rise apartment building. However, the apartment has a horrifying past. The previous occupant of the flat, a young woman had killed her child and jumped from the balcony and died. Swati learns about this incident shortly after moving in and becomes oddly fixated with the story. Then, a series of inexplicable experiences drive Swati to near madness. Vishal becomes helpless and convinced his wife has developed some sort of psychological disorder. He consults a psychiatrist, Dr. Rajan (Victor Banerjee). The couple's maid (Seema Biswas) believes Swati to be possessed, and calls in an exorcist (Rekha). Meanwhile, other seemingly unrelated events take place around the building. The watchman (Sabeer Masani) is being terrorized, one of the residents Sanjay (Fardeen Khan) is behaving erratically, and a murder occurs. Inspector Liaqat Quereshi (Nana Patekar) is sent to investigate the murder at the building. All the while, neither the psychiatrist nor the exorcist makes much progress with Swat。
